The Hereditary
Breast & Ovarian
Cancer Test

What the test is and how it works

BRCA1 and BRCA2 are two of the best-known genes involved in hereditary breast and ovarian cancer risk. What’s more, they’re found in up to 50% of families with both breast and ovarian cancer*.

PALB2 is another well-known gene and researchers have recently reported that mutations in this gene are now associated with a risk of breast cancer that’s nearly as high as the inherited BRCA1 and BRCA2 mutations*.

We also screen for potential genetic mutations associated with breast and ovarian cancer, in 13 other genes. ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PPM1D, PTEN, RAD51C, STK11, TP53.

Let’s look at the facts

Let’s look at the facts

Breast Cancer

The average lifetime risk of breast cancer for women is about 12%. That’s 1 out of 9 women. However, for women who have a BRCA1 or BRCA2 mutation, the risk of developing breast cancer in their lifetime is actually between 40% and 85%. That’s about 3 to 7 times higher than women who do not have the mutation.

Ovarian Cancer

The lifetime risk of ovarian cancer is around 2% for women. However, women who have a BRCA1 or BRCA2 mutations have a significantly elevated risk of 16% to 44%.

Faulty BRCA genes

Faulty BRCA genes affect around 1 in every 400 people. However, people of Ashkenazi Jewish descent are at a much higher risk: as many as 1 in 40 may carry the faulty gene.

Before you take a test,
take a breath

At Myogenes we’re here to help put your mind at rest and not increase any potential anxiety. That’s why it’s important to take a moment to understand the potential advantages and disadvantages of taking a test in the first place. It’s also worth keeping in mind that even a positive test result doesn’t mean that you will develop cancer in the future – it’s all about being aware of the risks.

keeping in mind that even a positive test result doesn’t mean that you will develop cancer in the future – it’s all about being aware of the risks.

The Pros

Knowledge is power, and early cancer detection dramatically improves your chances of a cure. Knowing your risk levels can enable you to manage your health proactively. For example, you can work with your doctor on a screening programme that may start at a younger age to help detect cancer at the earliest possible stage. If your test highlights mutations, then your doctor may prescribe preventative medication to reduce cancer risks, and individuals who are deemed at higher risk for cancer may also benefit from risk-reducing surgery.

Your family members can also determine their risk status and take charge of their own personal health. Parents, siblings, and children have up to a 50% chance of carrying the same mutation.

On the other hand, learning that you do not carry a gene variant that predisposes to hereditary cancer risk is also valuable and reassuring information.

The Cons

The results of some genetic tests are inconclusive, for example, doctors may identify a variation in a gene, but not know exactly what effect, if any, it may have. This type of result has the potential to cause anxiety for some people. Therefore, it’s important to ask yourself if you’d really like to know your own personal genetic risk levels of developing cancer in the future.

What does a positive test mean?

If your predictive genetic test result is positive, it means you have a faulty gene that raises your risk of developing cancer. However, it’s important to understand that it doesn’t mean you are guaranteed to get cancer in the future. Your genes only partly influence your future health risks. Other factors, such as your medical history, lifestyle and your environment, also play a key role. If you have one of the faulty BRCA genes, there is a 50% chance you will pass this on to your children and a 50% chance that each of your siblings may also have it.

Your test and results

At Myogenes we use a state-of-the-art genetic test developed by Cellmax for identifying hereditary cancer susceptibility mutations. The test uses advanced next-generation sequencing (SMSEQTM) targeting 98 genes with a high-degree of analytical sensitivity and specificity. Validation using industry-standard methods yielded an accuracy of 99.99%. The genetic panel includes 98 genes reported in the literature as being associated with increased risk for 24 hereditary cancers, including breast, ovarian, prostate cancer.

Your physical and mental wellbeing is always our top priority. Regardless of the results, you’ll always be taken through your detailed test report by a healthcare professional of your choice who can explain the individual findings and make a detailed plan for the future.

HOW TO GET A TEST

Arranging your Hereditary Breast and Ovarian Cancer Test now

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Monday - Friday

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Call +44 (0)20 8387 1266

Office hours are:
9:00am - 5:30pm
Monday - Friday

We look forward to hearing from you soon